ketogene Mittelmeer-Diät
Eine Pilotstudie der spanischen Mittelmeer-Diät Ketogene: eine
wirksame Therapie für das metabolische Syndrom.
J Med Food. 2011 Jul-Aug;14(7-8):681-7. Epub 2011 May 25.
A pilot study of the Spanish Ketogenic Mediterranean Diet: an
effective therapy for the metabolic syndrome.
Pérez-Guisado J, Muñoz-Serrano A.
Source
Department of Genetics, University of Córdoba, Córdoba, Spain. pv1peguj@uco.es
Abstract
The "Spanish Ketogenic Mediterranean Diet" (SKMD) has been shown to
promote potential therapeutic properties for the metabolic syndrome.
The purpose of this study was to evaluate the potential therapeutic
properties under free-living conditions of the SKMD in patients with
metabolic syndrome (following the International Diabetes Federation
consensus guidelines) over a 12-week period. A prospective study was
carried out in 22 obese subjects with metabolic syndrome (12 men and
10 women) with the inclusion criteria whose body mass index of 36.58 ±
0.54 kg/m² and age was 41.18 ± 2.28 years. Statistical differences
between the parameters studied before and after the administration of
the SKMD (week 0 and 12, respectively) were analyzed by paired
Student's t test. There was an extremely significant (P < .001)
improvement in low-density lipoprotein cholesterol (from 126.25 mg/dL
to 103.87 mg/dL) and all the parameters studied associated with
metabolic syndrome: body weight (from 106.41 kg to 91.95 kg), body
mass index (from 36.58 kg/m² to 31.69 kg/m²), waist circumference
(from 111.97 cm to 94.70 cm), fasting plasma glucose (from 118.81
mg/dL to 91.86 mg/dL), triacylglycerols (from 224.86 mg/dL to 109.59
mg/dL), high-density lipoprotein cholesterol (from 44.44 to 57.95
mg/dL), systolic blood pressure (from 141.59 mm Hg to 123.64 mm Hg),
and diastolic blood pressure (from 89.09 mm Hg to 76.36 mm Hg). The
most affected parameter was the triacylglycerols (51.26% reduction).
After the diet all the subjects were free of metabolic syndrome
according to the International Diabetes Federation definition, and
100% of them had normal triacylglycerols and high-density lipoprotein
cholesterol levels, in spite of the fact that 77.27% of them still had
a body mass index of > 30 kg/m². We conclude that the SKMD could be an
effective and safe way to cure patients suffering from metabolic
syndrome. Future research should include a larger sample size, a
longer-term use, and a comparison with other ketogenic diets.
http://www.ncbi.nlm.nih.gov/pubmed/21612461
Spanisch Ketogene Mittelmeer-Diät: eine gesunde Herz-Kreislauf-Diät
zur Gewichtsreduktion.
Nutr J. 2008 Oct 26;7:30.
Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet
for weight loss.
Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A.
Source
Department of Genetic, University of Córdoba, Campus of Rabanales,
Córdoba, Spain. pv1peguj@uco.es
Abstract
BACKGROUND:
Ketogenic diets are an effective healthy way of losing weight since
they promote a non-atherogenic lipid profile, lower blood pressure and
decrease resistance to insulin with an improvement in blood levels of
glucose and insulin. On the other hand, Mediterranean diet is well
known to be one of the healthiest diets, being the basic ingredients
of such diet the olive oil, red wine and vegetables. In Spain the fish
is an important component of such diet. The objective of this study
was to determine the dietary effects of a protein ketogenic diet rich
in olive oil, salad, fish and red wine.
METHODS:
A prospective study was carried out in 31 obese subjects (22 male and
19 female) with the inclusion criteria whose body mass index and age
was 36.46 +/- 2.22 and 38.48 +/- 2.27, respectively. This Ketogenic
diet was called "Spanish Ketogenic Mediterranean Diet" (SKMD) due to
the incorporation of virgin olive oil as the principal source of fat
(> or =30 ml/day), moderate red wine intake (200-400 ml/day), green
vegetables and salads as the main source of carbohydrates and fish as
the main source of proteins. It was an unlimited calorie diet.
Statistical differences between the parameters studied before and
after the administration of the "Spanish Ketogenic Mediterranean diet"
(week 0 and 12) were analyzed by paired Student's t test.
RESULTS:
There was an extremely significant (p < 0.0001) reduction in body
weight (108.62 kg--> 94.48 kg), body mass index (36.46 kg/m(2)-->31.76
kg/m(2), systolic blood pressure (125.71 mmHg-->109.05 mmHg),
diastolic blood pressure (84.52 mmHg--> 75.24 mmHg), total cholesterol
(208.24 mg/dl-->186.62 mg/dl), triacylglicerols (218.67 mg/dl-->113.90
mg/dl) and glucose (109.81 mg/dl--> 93.33 mg/dl). There was a
significant (p = 0.0167) reduction in LDLc (114.52 mg/dl-->105.95
mg/dl) and an extremely significant increase in HDLc (50.10
mg/dl-->54.57 mg/dl). The most affected parameter was the
triacylglicerols (47.91% of reduction).
CONCLUSION:
The SKMD is safe, an effective way of losing weight, promoting
non-atherogenic lipid profiles, lowering blood pressure and improving
fasting blood glucose levels. Future research should include a larger
sample size, a longer term use and a comparison with other ketogenic
diets.
http://www.ncbi.nlm.nih.gov/pubmed/18950537
Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet
for weight loss
Nutrition Journal 2008,
http://www.nutritionj.com/content/7/1/30